ACRP : ACRP-CP Questions & Answers

Last Updated: Aug 16, 2026

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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Topic 1: Ethical and Participant Safety Considerations19%- Safety monitoring and reporting
  • 1. Adverse event identification and classification
  • 2. Safety information evaluation and communication
- Ethical principles
  • 1. Human subject protections and privacy
  • 2. Clinical equipoise and therapeutic misconception
- Clinical care and management of research participants
  • 1. Continuity of medical care
  • 2. Standard of care vs protocol requirements
  • 3. Informed consent development and review
Topic 2: Clinical Study Operations15%- Project management
  • 1. Vendor and stakeholder management
  • 2. Timeline and budget management
- Site management
  • 1. Study documentation and record keeping
  • 2. Site personnel training and delegation
Topic 3: Regulatory and Compliance Requirements17%- International standards
  • 1. Declaration of Helsinki
- ICH Guidelines
  • 1. E6(R2)/E6(R3) Good Clinical Practice
  • 2. E2A Expedited Reporting
  • 3. E9 Statistical Principles
  • 4. E11 Pediatric Trials
  • 5. E8 General Considerations for Clinical Trials
- Compliance procedures
  • 1. Audits and inspections
  • 2. Regulatory submissions and approvals
Topic 4: Data Management and Informatics17%- Data collection
  • 1. Electronic data capture systems
  • 2. Case report form design and completion
- Data quality control
  • 1. Data validation and cleaning
  • 2. Query management and resolution
- Data reporting
  • 1. Data integrity and security
  • 2. Database lock and data transfer
Topic 5: Professionalism and Ethical Practice15%- Professional standards
  • 1. Role responsibilities and boundaries
  • 2. Confidentiality and conflict of interest
- Continuous improvement
  • 1. Quality assurance and process improvement
  • 2. Professional development and education
Topic 6: Study Design and Conduct17%- Study implementation
  • 1. Site selection and activation
  • 2. Study monitoring and oversight
  • 3. Investigational product management
- Study planning
  • 1. Study population and eligibility criteria
  • 2. Protocol development and amendments
  • 3. Sample size and statistical considerations

ACRP Certified Professional Sample Questions:

1. The process of ensuring and documenting that an electronic data processing system conforms to the sponsor's established requirements for completeness, accuracy, reliability, and consistent intended performance is called:

A) Quality Assurance
B) Programming
C) Validation
D) Quality Control


2. The IB contains which of the following sections?

A) Known pharmacokinetic effects
B) Participant dosing schedule
C) IP preparation instructions
D) Participant eligibility criteria


3. A PI on a study is a regular member of the IRB/IEC. Which of the following statements is TRUE regarding their participation in the IRB/IEC discussion and deliberation?

A) They must recuse themselves from the meeting given their dual roles as IRB/IEC member and PI.
B) They cannot be the PI on the clinical study due to conflict of interest.
C) They can attend the meeting and can vote/provide opinion on whether to approve the study.
D) They can attend the meeting, but should not vote/provide opinion on whether to approve the study.


4. Who takes responsibility for initiating a clinical trial?

A) Sponsor
B) Investigator
C) CRO
D) IRB/IEC


5. An investigator participating in a multicenter clinical trial has had 2 of the 4 subjects admitted to the emergency room for life-threatening infections. The investigator made the decision to stop treatment with IP and test for infections in the remaining subjects. What are the NEXT steps the investigator should take?

A) Notify the sponsor of the change in study plan and submit the deviation to the IRB/IEC for review.
B) Add the risk of infection to the ICF and submit to the IRB/IEC for review.
C) Update the IB to add the risk of infection and submit to the sponsor for approval.
D) Discontinue current subjects from the study and monitor subjects for any anticipated safety events.


Solutions:

Question # 1
Answer: C
Question # 2
Answer: A
Question # 3
Answer: A
Question # 4
Answer: A
Question # 5
Answer: A

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