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| Section | Weight | Objectives |
|---|---|---|
| Patient-Centered Pharmacotherapy | 65% | - Therapeutic guidelines and evidence-based treatment - Pharmacokinetics and pharmacodynamics - Adverse drug reactions and interactions - Drug selection, dosing, and monitoring - Pathophysiology and clinical presentation |
| Healthcare Systems and Population Health | 10% | - Population-based pharmacotherapy - Medication safety and quality improvement - Regulatory and economic considerations - Healthcare delivery models |
| Application of Evidence to Practice and Education | 25% | - Literature evaluation and biostatistics - Drug information and communication - Clinical research and guideline development - Patient education and counseling |
Question 1
A 72-year-old man has chronic insomnia that has not responded to measures to improve sleep hygiene. The patient is not depressed and has no other chronic health problems. It is determined that medication use will probably be necessary to manage the insomnia. What is the best initial recommendation for this patient?
A. Alprazolam
B. Trazodone
C. Diphenhydramine
D. Amitriptyline
Question 2
Two antihypertensive regimens have been compared in 50 patients with mild hypertension.
Treatment A decreased mean diastolic blood pressure to 81 mm Hg, and Treatment B decreased it to 85mm Hg (p = 0.08, a priori critical a = 0.05). The most reasonable interpretation of these results is that the difference between treatments is:
A. Statistically but not clinically significant.
B. Neither statistically nor clinically significant.
C. Clinically but not statistically significant.
D. Statistically and clinically significant.
Question 3
A 48-year-old African American woman presents with BP = 142/96 mm Hg. Serum chemistry values are all within normal ranges. Lifestyle modification was initiated 6 months ago when BP was 146/94 mm Hg. The pharmacotherapy specialist should recommend which of the following?
A. Atenolol 25 mg daily
B. Hydrochlorothiazide 12.5 mg daily
C. Losartan 25 mg daily
D. Continued lifestyle modification
Question 4
Prednisone 10 mg orally daily is prescribed for a 68-year-old 60-kg patient with acute temporal arteritis. The pharmacotherapy specialist would recommend which of the following?
A. Prednisone should be discontinued after 2 Weeks.
B. Dose should be increased to 20 mg daily.
C. Dose should be increased to 60 mg daily.
D. Dose should be decreased to 5 mg daily.
Question 5
A patient with a COPD exacerbation is treated with prednisone 40 mg daily for one week with improvement. To discontinue the prednisone, the most appropriate procedure would be which of the following?
A. Stopping prednisone administration without dose tapering.
B. Reducing the daily prednisone dose by 50% every day until the patient is off the drug.
C. Reducing the daily prednisone dose by 50% every other day until it is down to 10 mg daily, then reducing it by 25% every other day until the patient is off the drug.
D. Reducing the daily prednisone dose by 25% every day until the patient is off the drug.
Solutions:
| Question 1 Answer: B | Question 2 Answer: C | Question 3 Answer: B | Question 4 Answer: A | Question 5 Answer: A |
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